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<h4>Background</h4>Tobacco use prevalence rates are high among Spanish adolescents. Programming to counteract tobacco use is needed.<h4>Methods and findings</h4>The current study provides a one-year follow-up outcome evaluation of Project EX, an eight-session classroom-based curriculum. The intervention was tested using a randomized controlled trial with 1,546 Spanish students, involving three program and three control schools. Compared to the control condition, the program condition revealed a greater reduction in nicotine dependence (p < .05) and CO ppm levels (p < .001), and lower consumption of cigarettes at last month (p = .03).<h4>Conclusions</h4>Long-term outcomes of the Project EX classroom-based program are promising for adolescent prevention and possibly cessation in Spain.