Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness
oleh: Ji-Han Xia, Gong-Hong Wei
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2018-11-01 |
Deskripsi
The 19q13 allele rs11672691 has been reproducibly found in association with aggressive form of prostate cancer, yet the underlying mechanism remains totally unknown. We have recently uncovered a mechanism by which rs11672691 influenced a novel oncogenic regulatory circuit, including HOXA2, PCAT19 and CEACAM21, thereby contributing to prostate cancer aggressiveness.