Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells
oleh: Junji Xing, Ao Zhang, Yong Du, Mingli Fang, Laurie J. Minze, Yong-Jun Liu, Xian Chang Li, Zhiqiang Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-05-01 |
Deskripsi
Innate immune cells play critical roles patrolling for and detecting viral infection by expression of a range of nucleic acid sensors. Here the authors implicate PARP9 in the detection of viral RNA and the induction of the IFN pathway via PI3K/AKT3.