Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin
oleh: Baijun Ye, Peng Jiang, Tingrong Zhang, Yuanjun Sun, Xin Hao, Yingjun Cui, Liang Wang, Yue Chen
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2018-09-01 |
Deskripsi
The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.