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Obesity is one of the leading global health problems in the world today. It is considered a major risk factor for many serious diseases. To treat this risk factor, doctors have developed invasive and noninvasive therapeutic methods. One of these methods is the intragastric balloons (IGBs), which are known by some studies to be efficient, safe, and easy. Here, we report five cases of obese patients (three women and two men) treated by saline-filled gastric balloon insertion at our hospital. The balloons were placed endoscopically in the stomach then inflated with saline + methylene blue. After the procedure, patients were discharged within a few hours. The IGB was removed 6 months later. All patients were followed for a minimum period of 6–12 months. The insertion of a gastric balloon gives good results in the reduction of weight in all five cases; it seems that the use of gastric balloon insertion in obese patients is an effective technique for weight loss.