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It is now more than half a century since I spent a year in Moscow as a post-doctoral fellow working under the supervision of Alexander Romanovich Luria. That experience and the 15 years during which we corresponded and organized translations have fundamentally shaped my scientific career. Simultaneously the reach and influence of Luria’s ideas have continued to diffuse throughout modern scientific psychology.The following remarks are intended to suggest some of the recent accomplishments and current issues facing those who have adopted a Lurian approach, which traces its origins back to the 1920’s. In my view, the development of a cultural-historical psychology will depend greatly on the degree to which it can guide efforts at life-generating, socially sanctioned, new forms of activity in health, in education, in preparation to confront the challenges to human existence posed by human beings themselves.