Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis
oleh: Avijit Ray, Mohamed I. Khalil, Kirthi L. Pulakanti, Robert T. Burns, Cody J. Gurski, Sreemanti Basu, Demin Wang, Sridhar Rao, Bonnie N. Dittel
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-01-01 |
Deskripsi
B cells produce antibodies to mediate various immune functions, but are also reported to negatively regulate immune responses. Here, the authors show that a subset of mature B cells expressing low levels of IgD, present in both mice and human, may pursue this regulatory function indirectly by inducing the proliferation of regulatory T cells via GITRL.