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Abstract Background We describe a prototype implementation of a platform that could underlie a Precision Oncology Rapid Learning system. Results We describe the prototype platform, and examine some important issues and details. In the Appendix we provide a complete walk-through of the prototype platform. Conclusions The design choices made in this implementation rest upon ten constitutive hypotheses, which, taken together, define a particular view of how a rapid learning medical platform might be defined, organized, and implemented.