Iron induces two distinct Ca2+ signalling cascades in astrocytes
oleh: Wenzheng Guan, Maosheng Xia, Ming Ji, Beina Chen, Shuai Li, Manman Zhang, Shanshan Liang, Binjie Chen, Wenliang Gong, Chengyi Dong, Gehua Wen, Xiaoni Zhan, Dianjun Zhang, Xinyu Li, Yuefei Zhou, Dawei Guan, Alexei Verkhratsky, Baoman Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-05-01 |
Deskripsi
Wenzheng Guan and Maosheng Xia et al. use a combination of pharmacological, genetic, and calcium imaging approaches to describe two mechanisms of iron-induced astrocytic calcium signaling. Altogether, these results suggest that astrocytes may act as a barrier to excessive iron in the brain, thereby improving our understanding of the role of astrocytes in normal neurodevelopment.