BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice
oleh: Stephanie Perkail, Jaclyn Andricovich, Yan Kai, Alexandros Tzatsos
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-06-01 |
Deskripsi
Chronic pancreatitis is linked with an increased risk of pancreatic cancer. Here the authors show that genomic instability due to the loss of BRCA1 associated protein-1, frequently observed in patients with pancreatic cancer, is associated with chronic pancreatitis and predisposes to cancer development.