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Discovery of Drug Candidates for Specific Human Disease Based on Natural Products of Gut Microbes
oleh: Cheng-Yu Wang, Qing-Feng Wen, Qiao-Qiao Wang, Xia Kuang, Chuan Dong, Zi-Xin Deng, Feng-Biao Guo
Format: | Article |
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Diterbitkan: | Frontiers Media S.A. 2022-06-01 |
Deskripsi
The beneficial metabolites of the microbiome could be used as a tool for screening drugs that have the potential for the therapy of various human diseases. Narrowing down the range of beneficial metabolite candidates in specific diseases was primarily a key step for further validation in model organisms. Herein, we proposed a reasonable hypothesis that the metabolites existing commonly in multiple beneficial (or negatively associated) bacteria might have a high probability of being effective drug candidates for specific diseases. According to this hypothesis, we screened metabolites associated with seven human diseases. For type I diabetes, 45 out of 88 screened metabolites had been reported as potential drugs in the literature. Meanwhile, 18 of these metabolites were specific to type I diabetes. Additionally, metabolite correlation could reflect disease relationships in some sense. Our results have demonstrated the potential of bioinformatics mining gut microbes' metabolites as drug candidates based on reported numerous microbe-disease associations and the Virtual Metabolic Human database. More subtle methods would be developed to ensure more accurate predictions.