Structural basis of homo- and heterotrimerization of collagen I
oleh: Urvashi Sharma, Loïc Carrique, Sandrine Vadon-Le Goff, Natacha Mariano, Rainier-Numa Georges, Frederic Delolme, Peppi Koivunen, Johanna Myllyharju, Catherine Moali, Nushin Aghajari, David J. S. Hulmes
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-03-01 |
Deskripsi
Heterotrimers of collagen I (two α1 chains, one α2 chain) are crucial for the normal function of multiple tissues and organs. Here the authors show the molecular basis of both homotrimerization (three α1 chains) and heterotrimerization of collagen I through specific intermolecular interactions.