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Hematuria is one of the most important clinical manifestations, dating back in antiquity to more than a thousand years ago. In this paper, we tried to give a brief history of hematuria in Persian medicine and compare its similarities with Modern medicine. The importance of this issue is to give a better cognition of hematuria in the Persian medicine viewpoint in comparison with Modern medicine and also to understand the antiquity of hematuria, using simple and accessible therapies, provide a background for further studies in this field, and ultimately help improve Modern medicine in order to have a better treatment package, along with managing the costs.