ASK1 inhibits browning of white adipose tissue in obesity
oleh: Fabrizio C. Lucchini, Stephan Wueest, Tenagne D. Challa, Flurin Item, Salvatore Modica, Marcela Borsigova, Yulia Haim, Christian Wolfrum, Assaf Rudich, Daniel Konrad
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-04-01 |
Deskripsi
Understanding the regulatory mechanisms governing brown and beige adipose mediated thermogenesis is of interest in order to develop therapeutic strategies to treat obesity. Here, the authors show that adipocyte-expressed apoptosis signal-regulating kinase 1 (ASK1) inhibits browning in response to cold, β3 receptor activation, and LPS.