Find in Library

Dorsal root ganglia (DRG) neurons are the primary afferent neurons of algaesthesis of trunk and extremities. DRG transmits and accommodates sensations and accepts and conveys nociception, so it plays an important role in the mechanism of pain. DRG is accessible to clinical interventions for the control of intractable pain and is a target for neuromodulation therapy. This review focuses on sodium ion channels in DRG, glial cells and inflammatory reaction which are mainly involved in the mechanism of pain. DOI: 10.3969/j.issn.1672-6731.2018.10.002