Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
oleh: In Young Hwang, Elvin Koh, Adison Wong, John C. March, William E. Bentley, Yung Seng Lee, Matthew Wook Chang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-04-01 |
Deskripsi
Bacteria can be engineered to kill specific pathogens. Here, the authors modify and optimize a synthetic genetic system in a probiotic strain ofEscherichia coli, and show that the engineered probiotic can sense and kill the pathogen Pseudomonas aeruginosain two animal models of gut infection.