The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

oleh: Philippe Coulombe, Joelle Nassar, Isabelle Peiffer, Slavica Stanojcic, Yvon Sterkers, Axel Delamarre, Stéphane Bocquet, Marcel Méchali

Format: Article
Diterbitkan: Nature Portfolio 2019-06-01

Deskripsi

DNA replication is initiated at defined genomic sites called origins of replication following ORC pre-replicative complex assembly. Here the authors identify a protein ubiquitylating ORC that is involved in origin activation and may act as a selector of origins to be fired.