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Staphylococcal toxic shock syndrome (STSS) is a toxin-mediated disease. It is a severe fatal disease inducing immune-mediated inflammatory reaction and occurs because of exotoxin produced by Staphylococcus aureus. Common signs and symptoms at the time of presentation lead to misdiagnosis and delay in initiation of treatment. Prognosis depends primarily on early diagnosis and prompt treatment. This is a case of a young adult male presented with fever, rash, and hypotension and diagnosed with STSS.