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<strong>Context:</strong> The present review attempts to distinguish some management, challenges and solutions to drug dependency of women. The issues make clear the need for accomplishing different prevention and management strategies in both genders. <strong>Evidence Acquisition:</strong> The present review comprised data of related domain from different printed and online data bases such as UN, SID, ISC, Medline, ISI and etc., as well-known sources of scientific studies. <strong>Results:</strong> The review of data in corresponding domain presented two distinct sections which are challenges of addiction in women, and strategies for sufficient treatment of addicted women which include some underlying strategic subcomponents. <strong>Conclusions:</strong> As indicated by the studies, serious attention must be paid to the treatment needs of women, regarding tools, and practical and potentially equal strategies necessary for having a healthy community.