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Background: Aim: Results: Conclusion: .key words :hepatitis C,leukemia, pediatrics Treatment with Amlodipine can be used to control portal hypertension in leukemic children having hepatitis c virus induced portal hypertension. From this study, we found that Amlodipine was effective in reducing the elevated portal blood pressure to normal level in doses which doesnot interfer with mechanism of action of chemotherapy In the present study we tested the effect of Amlodipine on children of acute lymphoblastic leukemia having portal hypertention secondary to hepatitis c infection during maintenance chemotherapy Children with acute leukemia are at high risk of hepatitis C infection, either by imunosuppression secondary to chemotherapy or by multiple transfusions of blood products during the course of the disease. Hepatitis C constitute a major problem during management of acute leukemias due to resultant Portal hypertension, or bleeding esophageal varices. Chronic HCV infection is a major cause of liver cirrhosis and hepatocellular carcinoma in leukemic survivors.