NetREX-CF integrates incomplete transcription factor data with gene expression to reconstruct gene regulatory networks
oleh: Yijie Wang, Hangnoh Lee, Justin M. Fear, Isabelle Berger, Brian Oliver, Teresa M. Przytycka
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
NetREX-CF is a computational method that integrates collaborative filtering and a mathematical model of transcriptional regulation to predict gene regulatory networks from incomplete transcription factor (TF) binding data and context-specific gene expression. NetREX-CF is used to obtain a comprehensive regulatory network and benchmark resource for Drosophila Schneider 2 cells.