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Multiple malignant tumors, synchronous, metachronous, represent a subject currently under development. Risk assessment, standardization of screening and and to map the sequences of the occurrence and localization represents current issues. For further study, we evaluated 30 patients who developed 3 or more malignancies. The study has a retrospective character, the information being obtained from the history and the medical documents of the patients admitted to the General Surgery II of the Bucharest Emergency Hospital during 2010-2019.