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<strong>Objective</strong> To observe the curative effect and life quality improvement in patients with intractable neuropathic pain (NP) after implanting a programmable continuous intrathecal infusion pump. <strong>Methods</strong> Three cases of intractable neuropathic pain with poor medicine efficacy or serious adverse drug reactions had been followed-up for 6-14 months after being implanted programmable intrathecal infusion pump. Pain relief, sleep quality improvement, dosage of oral analgesics and drug side effect were observed. <strong>Results</strong> After treatment the Visual Analogue Scale (VAS) of 3 patients decreased significantly, with pain releasing from preoperative moderate or severe pain to postoperative mild pain and decrease of fulminating pain frequency. Dosage of oral analgesics declined to 10% of its preoperative dose and sleep quality was improved obviously. Neither postoperative complications nor side effect of morphine was observed during the follow-up. <strong>Conclusion</strong> The treatment of implanting a totally programmable continuous intrathecal infusion pump is eutherapeutic to the patients with intractable neuropathic pain who have achieved satisfactory analgesic effect in experimental therapy.