The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen
oleh: Gwen-Jirō Clochard, Aby Mbengue, Clément Mettling, Birane Diouf, Charlotte Faurie, Omar Sene, Emilie Chancerel, Erwan Guichoux, Guillaume Hollard, Michel Raymond, Marc Willinger
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
Abstract It has been shown that living in risky environments, as well as having a risky occupation, can moderate risk-tolerance. Despite the involvement of dopamine in the expectation of reward described by neurobiologists, a GWAS study was not able to demonstrate a genetic contribution of genes involved in the dopaminergic pathway in risk attitudes and gene candidate studies gave contrasting results. We test the possibility that a genetic effect of the DRD4-7R allele in risk-taking behavior could be modulated by environmental factors. We show that the increase in risk-tolerance due to the 7R allele is independent of the environmental risk in two populations in Northern Senegal, one of which is exposed to a very high risk due to dangerous fishing.