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Integral rheological properties of the blood serum in patients with osteoarthritis depend on the presence of all components of the metabolic syndrome (primarily on the parameters of insulinemia, the severity of insulin resistance, body mass index, uricemia, lipidemia, type of hyperlipidemia, the nature of hypertension and peripheral vascular resistance), and in the pathogenesis of such signs as osteophytosis, osteocystosis, osseous erosion, osteoporosis, subchondral sclerosis, damage of the meniscus, the development of Baker’s cysts and enthesiopathies, the indicators of adsorption-glycemic integral coefficient, glycemic coefficient of interfacial activity, viscoelastic modulus, static surface tension and phase angle tensiogram.