DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
oleh: Wendan Ren, Huitao Fan, Sara A. Grimm, Jae Jin Kim, Linhui Li, Yiran Guo, Christopher James Petell, Xiao-Feng Tan, Zhi-Min Zhang, John P. Coan, Jiekai Yin, Dae In Kim, Linfeng Gao, Ling Cai, Nelli Khudaverdyan, Burak Çetin, Dinshaw J. Patel, Yinsheng Wang, Qiang Cui, Brian D. Strahl, Or Gozani, Kyle M. Miller, Seán E. O’Leary, Paul A. Wade, Gang Greg Wang, Jikui Song
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-05-01 |
Deskripsi
How histone modifications crosstalk with DNA methylation to regulate epigenomic patterning and genome stability in mammals remains elusive. Here, the authors show that DNA methyltransferase DNMT1 is a reader for histone H4K20 trimethylation via its BAH1 domain, which leads to optimal maintenance of DNA methylation at repetitive LINE-1 elements.