From the first touch to biofilm establishment by the human pathogen Candida glabrata: a genome-wide to nanoscale view
oleh: Mafalda Cavalheiro, Diana Pereira, Cécile Formosa-Dague, Carolina Leitão, Pedro Pais, Easter Ndlovu, Romeu Viana, Andreia I. Pimenta, Rui Santos, Azusa Takahashi-Nakaguchi, Michiyo Okamoto, Mihaela Ola, Hiroji Chibana, Arsénio M. Fialho, Geraldine Butler, Etienne Dague, Miguel C. Teixeira
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-07-01 |
Deskripsi
Mafalda Cavalheiro et al. use single-cell force spectroscopy and RNA-seq to examine the adhesion process of Candida glabrata, an opportunistic human fungal pathogen, to various medical surfaces. Their results suggest that the adhesion forces of C. glabrata to medical material are stronger than those presented for epithelial cells, and highlight the underlying molecular pathways related to adhesion and biofilm formation in this species.