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Indiscriminate use of pesticides for the past 40 years has almost eliminated natural enemies from many crop ecosystems. An experiment has been carried out in the   laboratory to determine the efficacy of NPV (Nucleopolyhedrosis virus) against C.partellus in the stalk borer, Chilo partellus (Swinhoe) pest management during 2004-2006. The C. partellus larvae were found maximum infection at 400-500 ppm concentration and the mortality were observed 80 to 90%.