A rare case of aseptic herpes simplex virus-1 meningitis in a patient with recent COVID-19

oleh: Maria Dimitrova, Violeta Yotova, Kristina Dimitrova

Format: Article
Diterbitkan: Pensoft Publishers 2022-02-01

Deskripsi

The aim of presenting this case was to show the difficulties in making the differential diagnosis of viral meningitis during the COVID pandemic situation.We report a case of a young man with clinical features of viral meningitis and with epidemiological history of COVID-19 in his family. The patient complained of fever, headache, photophobia, nausea, myalgia, and fatigue. He gave a history of diarrhea and vomiting two weeks before admission and close relatives with COVID-19. The neurological examination revealed a meningeal irritation syndrome. The diagnostic tests we performed were as follows: nasopharyngeal swab and PCR of cerebrospinal fluid (CSF) for SARS CoV-2, computed tomography scan of the head, general CSF examination, viral tests, and microbiology of CSF, enzyme-linked immunosorbent assay (ELISA) IgM and IgG.The results were consistent with viral meningitis due to HSV-1 in simultaneously found high titres of plasma SARS CoV-2 specific IgA and SARS CoV-2 specific IgG and active viral serum infection for CMV and EBV.