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Tumor lysis syndrome (TLS) is a potentially lethal emergency causedby lysed tumor cells, and it frequently occurs in tumors of hematologic origin. Up until now, there has been only one known reportpublished overseas about TLS resulting from post-transplant lymphoproliferative disorder (PTLD)[1]. In 2008, a PTLD patient whohad previously undergone renal transplantation was treated in therenal transplantation center of our hospital, and TLS occurred duringtreatment for PTLD. At the time, no further literature regarding thetreatment of post-transplant renal inadequacy complicating TLS wasavailable. So, continuous veno-venous hemofiltration (CVVH) wasused to effectively control the progression of TLS. In this article, the experiences gained from our management of this complex case andour analysis, supported by relevant literature, are described.