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Down syndrome is the most common chromosomal disorder associated with skin conditions, including psoriasis and hidradenitis suppurativa. Patients with Down syndrome are more likely to be overweight or obese and diagnosed with metabolic comorbidities such as cardiovascular disorders, inflammatory joint diseases as in psoriasis and hidradenitis suppurativa. Although both hidradenitis suppurativa and psoriasis are associated with Down syndrome, concurrent psoriasis and hidradenitis suppurativa in the same patient with Down syndrome have not been reported in the literature. Here, we describe three patients with Down syndrome having both hidradenitis suppurativa and psoriasis by discussing the common etiopathogenesis considering the current literature.