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Purpose: To report the use of Spectralis High Magnification Module (HMM) as part of multimodal imaging in Multiple Evanescent White Dot Syndrome (MEWDS). Observations: HMM imaging showed a blurry mosaic pattern corresponding to MEWDS-related photoreceptors’ lesions. These abnormalities remained detectable at later stages of the disease while other imaging modalities were negative. Conclusions and importance: HMM can be a useful technique to monitor the structure of the outer retina during the different stages of MEWDS.