Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma
oleh: Nguyen Thuy Linh, Ngo Thu Hang, Bui Khac Cuong, Dang Thuy Linh, Nham Thi Phuong Linh, Do Nguyen-Van, Tran Ngoc Dzung, Can Van Mao, Dang Thanh Chung, Le Tri Chinh, Nguyen Phu Hung, Hoang Van Tong, Nguyen Linh Toan
| Format: | Article |
|---|---|
| Diterbitkan: | Future Science Ltd 2023-09-01 |
Deskripsi
Aim: Ovarian cancer is a serious malignancy with high prevalence and mortality. Methods: We isolated and characterized an ovarian high-grade serous cancer cell line (M4) from a tumor of a Vietnamese patient with ovarian carcinoma. Results: The M4 cancer cell line showed good proliferation and stability in culture. Morphologically, the M4 cells showed similar characteristics to tumor cells such as a polyhedral shape, large irregular nuclei, high nuclear/cytoplasmic ratio, high nuclear density and expressing cancer markers like CA125, p53 and Ki67 markers. Conclusion: We have successfully isolated and characterized the M4 cell line from a Vietnamese patient with ovarian carcinoma.