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Epidermolysis Bullosa (EB) is a group of inherited skin fragility disorders. It characteristically presents as blisters formation over skin and mucosa. Epidermolysis bullosa simplex, junctional epidermolysis bullosa and dystrophic epidermolysis bullosa are three major subtypes of EB depending on the level of skin cleavage. Present case report describes a rare junctional epidermolysis bullosa in a newborn. Clinical manifestations vary from mild local blisters formation to severe one with multisystem involvement. Protection of skin, prevention of complications and supportive care are the only current treatment options.