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A study was conducted to evaluate role of complement proteins and complement receptor 1 (CR1) in pathogenesis of Systemic lupus erythematosus (SLE) and Immune complex (IC) mediated glomerulonephritis. C3, C4, C3d and CH100 in serum, CR1 in renal biopsies and RBC showed these parameters to be of great diagnostic and prognostic values in Immune complex mediated diseases. Our study revealed an overall decrease in levels of CR1, C3, C4 in IC mediated as compared to non - IC mediated disease. Whereas C3d in case of SLE 247 ± 39 AU/L including IC mediated Glomerulonephritis (ICGN) 208 ± 51 AU/L was found to be significantly increased (P < 0.05) than normal control 46 ± 6 AU/L. There was no appreciable increase in case of non - 1C mediated GN (61 ± 12 AU/L) CRI among SLE patients (261 ± 141/E) and IC mediated group (270 ± 107/E) was found to be significantly lower (P < 0.05) than normal control (627 ± 132/E) and non - IC GN (550 ± 86/E). C4 values among SLE, patients were found to be 191 ± 104 mg/L as compared to control (286 ±110 mg/ L). The kidney biopsy of type III and type IV lupus nephritis revealed a complete absence of CR1 in contrast to minimal change diseases. Thus this study revealed that above parameters could be a valuable tool for distinguishing IC versus non-IC mediated kidney diseases. Key Words: Complement receptor 1 (CR1) Glomerulonephritis, SLE.