A comprehensive overview of genomic imprinting in breast and its deregulation in cancer
oleh: Tine Goovaerts, Sandra Steyaert, Chari A. Vandenbussche, Jeroen Galle, Olivier Thas, Wim Van Criekinge, Tim De Meyer
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-10-01 |
Deskripsi
In growth and development genomic imprinting is important in regulating gene expression. Here, the authors study loss of imprinting (LOI) in cancer, developing a mixture model to detect monoallelically expressed loci without genotyping data - applying this novel methodology to TCGA breast cancer data they find massive deregulation of imprinting.