Efficient Synthesis of 3‐Mercaptoindoles via HI‐Promoted Sulfenylation of Indoles with Sodium Sulfinates
oleh: Shengnan Sun, Hexia Ye, Haibo Liu, Dr. Yongbiao Guo, Zhenhua Gao, Dr. Li Pan, Dr. Junchen Li, Prof. Dr. Xiaojing Bi
| Format: | Article |
|---|---|
| Diterbitkan: | Wiley-VCH 2023-03-01 |
Deskripsi
Abstract A new direct sulfenylation method of indoles by sodium sulfinates and hydroiodic acid was developed giving variety of 3‐sulfenylindoles in high yields under mild conditions without using any catalysts or other additives. In situ‐generated RS‐I species are supposed to be mainly responsible for the key electrophilic alkyl‐ or aryl‐thiolation process.