Find in Library
Search millions of books, articles, and more
Indexed Open Access Databases
Clonal Hematopoiesis and Liquid Biopsy in Gastrointestinal Cancers
oleh: Vlad M. Croitoru, Vlad M. Croitoru, Irina M. Cazacu, Irina M. Cazacu, Ionut Popescu, Doru Paul, Simona Olimpia Dima, Simona Olimpia Dima, Adina Emilia Croitoru, Adina Emilia Croitoru, Alina Daniela Tanase, Alina Daniela Tanase
Format: | Article |
---|---|
Diterbitkan: | Frontiers Media S.A. 2022-01-01 |
Deskripsi
The use of blood liquid biopsy is increasingly being incorporated into the clinical setting of gastrointestinal cancers care. Clonal hematopoiesis (CH) occurs naturally as a result of the accumulation of somatic mutations and the clonal proliferation of hematopoietic stem cells with normal aging. The identification of CH-mutations has been described as a source of biological noise in blood liquid biopsy. Incorrect interpretation of CH events as cancer related can have a direct impact on cancer diagnosis and treatment. This review summarizes the current understanding of CH as a form of biological noise in blood liquid biopsy and the reported clinical significance of CH in patients with GI cancers.