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Resistant starch (RS) refers to the portion of starch that escapes intestinal digestion and reaches the colon where it can be fermented. RS in the diet may provide beneficial effects on individuals trying to reduce caloric intake and lose weight. Yet, current evidence on the impact of RS on appetite and satiety regulation is controversial, and the beneficial effect of RS in relieving obesity epidemic has been highly debated. This review aims to collect data from multiple primary research studies, as an effort to inform if RS can affect appetite and satiety in healthy, prediabetic, and overweight/obese adults, respectively. Multiple randomized crossover studies, randomized intervention studies, and parallel arm trials were analyzed in this review. The research of 22 studies showed inconclusive evidence that RS has any statistically significant effects on appetite, hunger, food intake, and satiety biomarkers in either type of individual. It is concluded that further studies and meta-analyses must be done in order to further evaluate the effect of RS on food intake and possible weight loss. Additionally, in future research designs on depicting RS and prevention of obesity and weight gain, it is recommended to consider the effect of RS on appetite and satiety regulation.