A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function
oleh: Jeremy To, Doug Quackenbush, Emily Rowell, Lilin Li, Connor Reed, Frederick Lo, Shane R. Horman
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
Jeremy To et al. develop an ultra-high-content assay platform used to interrogate T-cell-mediated killing of 3D multicellular tumor spheroids. They screen 1,800 annotated compounds to identify small molecules that enhance cytotoxic CD8+ T-cell activity in an antigen-dependent manner, demonstrating the utility of this assay platform.