Th17-inducing autologous dendritic cell vaccination promotes antigen-specific cellular and humoral immunity in ovarian cancer patients
oleh: Matthew S. Block, Allan B. Dietz, Michael P. Gustafson, Kimberly R. Kalli, Courtney L. Erskine, Bahaaeldin Youssef, Geraldine V. Vijay, Jacob B. Allred, Kevin D. Pavelko, Michael A. Strausbauch, Yi Lin, Megan E. Grudem, Aminah Jatoi, Carolyn M. Klampe, Andrea E. Wahner-Hendrickson, S. John Weroha, Gretchen E. Glaser, Amanika Kumar, Carrie L. Langstraat, Mary L. Solseth, Michael C. Deeds, Keith L. Knutson, Martin J. Cannon
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
The folate receptor alpha (FRα) is overexpressed in the majority of high-grade serous ovarian cancers and has been proposed as a candidate vaccine antigen. Here the authors report the safety and immunogenicity of Th17-inducing dendritic cells pulsed with FRα-derived epitopes in an early phase I clinical trial with ovarian cancer patients.