Oleiferasaponin A<sub>2</sub>, a Novel Saponin from <i>Camellia oleifera</i> Abel. Seeds, Inhibits Lipid Accumulation of HepG2 Cells Through Regulating Fatty Acid Metabolism
oleh: Tai-Mei Di, Shao-Lan Yang, Feng-Yu Du, Lei Zhao, Xiao-Han Li, Tao Xia, Xin-Fu Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2018-12-01 |
Deskripsi
A new triterpenoid saponin, named oleiferasaponin A<sub>2</sub>, was isolated and identified from <i>Camellia oleifera</i> defatted seeds. Oleiferasaponin A<sub>2</sub> exhibited anti-hyperlipidemic activity on HepG2 cell lines. Further study of the hypolipidemic mechanism showed that oleiferasaponin A<sub>2</sub> inhibited fatty acid synthesis by significantly down-regulating the expression of <i>SREBP-1c, FAS</i> and FAS protein, while dramatically promoting fatty acid β-oxidation by up-regulating the expression of <i>ACOX-1, CPT-1</i> and ACOX-1 protein. Our results demonstrate that the oleiferasaponin A<sub>2</sub> possesses potential medicinal value for hyperlipidemia treatment.