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In this paper, we study a nonisospectral semi-discrete Ablowitz–Kaup–Newell–Segur equation. Multisoliton solutions for this equation are given by Hirota’s method. Dynamics of some soliton solutions are analyzed and illustrated by asymptotic analysis. Multisoliton solutions and dynamics to a nonisospectral semi-discrete modified Korteweg-de Vries equation are also discussed.