Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase
oleh: Thibault Courtheoux, Radoslav I. Enchev, Fabienne Lampert, Juan Gerez, Jochen Beck, Paola Picotti, Izabela Sumara, Matthias Peter
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-09-01 |
Deskripsi
Although focal adhesions (FAs) and microtubules (MTs) are known to associate, the underlying regulation of this dynamic interaction is not understood. Here the authors discover that the CRL3KLHL21E3 ubiquitin ligase localises to FAs and ubiquitinates the MT plus-tip binding protein EB1, thereby promoting MT and FA dynamics and cell migration.