Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles
oleh: Ming Yuan Li, Trupti Shivaprasad Naik, Lewis Yu Lam Siu, Oreste Acuto, Eric Spooner, Peigang Wang, Xiaohan Yang, Yongping Lin, Roberto Bruzzone, Joseph Ashour, Matthew J Evans, Sumana Sanyal
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
Egress of flaviviruses and involved host pathways are not well understood. Here, the authors show that Lyn is a critical host kinase for Dengue and Zika virus egress resulting in infectious virus progenies within autophagosome-derived vesicles, which might help the virus to evade antibody responses.