Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
oleh: Yang Hai, Stephen A. Shinsky, Nicholas J. Porter, David W. Christianson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-05-01 |
Deskripsi
Polyamines bind to nucleic acids and their function is regulated by reversible acetylation. Here, the authors show that histone deacetylase 10 is a polyamine deacetylase and present its crystal structure with a bound polyamine transition state analogue inhibitor.