Secondary structural ensembles of the SARS-CoV-2 RNA genome in infected cells
oleh: Tammy C. T. Lan, Matty F. Allan, Lauren E. Malsick, Jia Z. Woo, Chi Zhu, Fengrui Zhang, Stuti Khandwala, Sherry S. Y. Nyeo, Yu Sun, Junjie U. Guo, Mark Bathe, Anders Näär, Anthony Griffiths, Silvi Rouskin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-03-01 |
Deskripsi
Lan et al. report RNA structure ensembles across the entire SARSCoV-2 genome in infected human cells at single nucleotide resolution. They find alternative RNA conformations critical for promoting near-native frameshifting rates in ORF1ab.