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Rezafungin is a next-generation echinocandin that has favorable pharmacokinetic properties. We compared the occurrence of paradoxical growth (PG) and trailing effect (TE) characteristics to echinocadins with rezafungin, caspofungin, micafungin and anidulafungin using 365 clinical <i>Candida</i> isolates belonging to 13 species. MICs were determined by BMD method according to CLSI (M27 Ed4). Disconnected growth (PG plus TE) was most frequent with caspofungin (49.6%), followed by anidulafungin (33.7%), micafungin (25.7%), while it was least frequent with rezafungin (16.9%). PG was relatively common in the case of caspofungin (30.1%) but was rare in the case of rezafungin (3.0%). <i>C. tropicalis</i>, <i>C. albicans</i>, <i>C. orthopsilosis</i> and <i>C. inconspicua</i> exhibited PG most frequently with caspofungin, micafungin or anidulafungin. PG never occurred in the case of <i>C. krusei</i> isolates. Against <i>C. tropicalis</i> and <i>C. albicans</i>, echinocandins frequently showed PG after 24 h followed by TE after 48 h. All four echinocandins exhibited TE for the majority of <i>C. auris</i> and <i>C. dubliniensis</i> isolates. Disconnected growth was common among <i>Candida</i> species and was echinocandin- and species-dependent. In contrast to earlier echinocandins, PG was infrequently found with rezafungin.