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Abstract Aim To determine the prevalence of self‐medication and reasons for self‐medication (SM) for the prevention/treatment of COVID‐19 among the adult population. Design Cross‐sectional study. Methods This study was performed on 147 adults in Kermanshah, Iran. Data were collected by a researcher‐made questionnaire and analysed by SPSS‐18 software using descriptive and inferential statistics. Results The prevalence of SM in the participants was 69.4%. Vitamin D and vitamin B complex were the most commonly used drugs. The most common symptoms leading to SM were fatigue and rhinitis. Strengthening the immune system and prevention of COVID‐19 (48%) were the main reasons for SM. Factors related to SM included marital status [OR = 8.04, 95% CI = (3.62, 17.83)], education [OR = 0.16, 95%CI = (0.08, 0.35)] and monthly income [OR = 0.09, 95%CI = (0.03, 0.26)]. Patient or Public Contribution Yes