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Mucoepidermoid carcinoma is considered to be one of the salivary gland-type cancers, which seldom originate from the lung. Herein, we report a 69-year-old female with primary pulmonary high-grade mucoepidermoid carcinoma. The disease progressed rapidly and reached an unresectable status. We treated the patient with bi-weekly doses of docetaxel and the clinical response allowed for the disease to become more stable. The patient survived for only six months from the onset of the symptoms. The case demonstrated that single use of docetaxel would appear to be a treatment option for mucoepidermoid carcinoma of the lung.